Protective effect of sesame (sesamum indicum) seed oil against hypercholesterolemic in sprague-dawley male rats

To explore the protective effect of sesame seed oil (SSO) extracted from Til-06 variety in Sprague-Dawley male rats against management hypercholesterolemia, current two-phase study was conducted. In first phase, taken out seeds (Til-06) and physicochemical analysis carried to find content following by evaluation quality attributes oil. second efficacy check hyperlipidemic activity Randomly distributed twenty (20) into 5 different groups with four (04) each group for 60 days fed as follow; on a basal diet, while other were 2, 4, 6 8% SSO plus diet. Blood samples collected at beginning end biochemical i.e. lipid profile which includes high-density lipoprotein (HDL-C), triglycerides (TG), low-density (LDL-C), total cholesterol (TC), very-low-density (VLDL) antioxidant status. Findings present indicate that oral administration significantly (P < 0.05) improved status lower TC, LDL-C, TG, VLDL-C, higher HDL-C values hypercholesterolemic rats.